Preparative TLC is used for purification and isolation of analytes from impurities on a larger scale than traditional TLC.
Prep TLC is a fast, inexpensive, and useful technique for the purification of small quantities of sample. It permits a rapid separation and isolation/recovery of components in a reaction mixture.
For preparative purposes, different layer thicknesses are available (500 µm, 1000 µm, and 2000 µm).
For 2000 µm preparative layers a slightly coarser material is used.
The isolated spots can be scraped from a prep plate, collected, and used for further downstream analysis.